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Coronavirus and smoking: How do cigarettes, pot and vaping affect infections and outcomes?

Smoking is associated with more severe outcomes for coronavirus patients, a recent study of studies has found.  (Jenny Kane / Associated Press)

In times of stress, like living through a global pandemic, it’s natural to fall back on soothing habits — gardeningplaying video games or, for some, lighting up a cigarette or taking a pull on a marijuana vape pen.

But what are the risks, given that the novel coronavirus at the center of the current crisis attacks the lungs?

The science is in its early stages, but studies are finding that cigarette smokers are more likely to have severe infections — a fact many lung doctors say doesn’t surprise them.

“It’s now pretty clear that there is data to show that if you are a smoker, you’re more likely to have adverse outcomes from COVID-19, need mechanical ventilation and to die than if you’re not a smoker,” said Richard Castriotta, a doctor specializing in pulmonary critical care at Keck Medicine of USC.

Smoking damages the lung’s defense mechanisms, making it harder to fight off COVID-19 and other respiratory diseases, according to several doctors who specialize in chest conditions like pneumonia, asthma and tuberculosis.

One of the disease’s main targets is the lungs, and injured lungs have more trouble fighting off COVID-19 and other respiratory diseases, Castriotta said.

What does science say?

Early data was conflicting. Some reports indicated that smoking was not associated with increased adverse outcomes and that smokers were underrepresented in hospital settings, leading some — such as the celebrated painter David Hockney — to claim that smokers might even have immunity to the virus that has claimed more than 1,500 lives in California.

Stanton Glantz, director of a tobacco research and education center at the University of California San Francisco, called the claims “really fringe stuff,” primarily being pushed by tobacco and vaping advocates. A meta-analysis helmed by his research team that combined data from 12 studies on the topic has debunked them, he said.

Current smokers face double the risk of disease progression, according to a pair of recent studies cited by Glantz. One study from China indicated that it increased the risk by a factor of four. Another study found that of those who died of COVID-19, 9% were current smokers, compared with 4% of those that survived.

“And that’s exactly what you’d expect, based on what we know about the biology,” Glantz said.

Smoking hinders the function of cilia, small hair-like projections that line the respiratory tract, which “beat up and out any kind of particles that are inhaled,” said Kathryn Melamed, a pulmonary and critical care physician at UCLA Medical Center.

Smoking also inhibits blood cells that would otherwise clean and repair damaged lungs, she said.

What about vaping?

Less is known about how coronavirus patients who use vaping and e-cigarette products are faring, given a dearth of relevant studies, but several doctors suspect their trajectory will mirror that of cigarette smokers.

“Vaping has all the same adverse effects as smoking does,” Glantz said.

Marijuana?

Messaging in the medical marijuana space has been to switch to edibles or tinctures if possible, although several doctors said they weren’t familiar with literature that looked at the impact of smoking cannabis on coronavirus infections.

That’s what Peter Grinspoon, a primary care physician in Boston and longtime medical marijuana advocate, said he’s advising patients to do.

“Two packs of cigarettes a day is obviously worse than a puff of cannabis a month, but smoking anything can irritate the lining of your lungs,” Grinspoon said.

He added: “It just seems intuitively true that if you irritate the lining of your lungs, you set yourself up for trouble in a disease that happens to cause most of its mortality by attacking your lungs.”

Cannabis sales in California have been booming during the pandemic, and Grinspoon said many patients are using it to treat anxiety likely exacerbated by the public health crisis. He said he supports the responsible use for those symptoms but cautioned inexperienced users to “start low and go slow” with the dosage to avoid increasing anxiety.

To Read The Rest Of This Article By Lila Seidman on Los Angeles Times

Published: April 23, 2020

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